What is MiST?
The Microbial Signal Transduction database contains the signal transduction proteins for 1,019 complete and 234 draft bacterial and archaeal genomes. These are identified using various domain profiles that directly or indirectly implicate a particular protein in participating in signal transduction.
Latest news
10 November 2009, 09:29 AM
08 October 2009, 10:34 AM
- Manuscript describing MiST2 has been accepted for publication in the upcoming NAR database issue!!
- Due to limited hardware resources, performing queries (especially against all genomes) is particuarly slow and may result in an internal error page. In the next couple months, we will migrate MiST2 to a dedicated server. This should substantially improve the performance and usability of this site. Thanks for your patience while we make this transition.
- Minor changes: Refseq gene name now displayed alongside all lists of proteins, added missing CheV classification.
28 September 2009, 09:37 AM
- Numerous bug fixes; finished help section last Friday evening.
- Significantly improved the search times (especially when searching the domain architecture). See the search help section to learn how to effectively query MiST2.
Citing MiST
If you use information from the MiST database in your research, please cite:
- The MiST2 database: a comprehensive genomics resource on microbial signal transduction.
Luke E. Ulrich and Igor B. Zhulin
Nucleic Acids Research, 2009, doi:10.1093/nar/gkp940.
Definitions of microbial signal transduction implemented in MiST are described in:
- One-component systems dominate signal transduction in prokaryotes.
Luke E. Ulrich, Eugene V. Koonin, and Igor B. Zhulin
Trends in Microbiology, 2005, 13:52-56.
Genomic distribution of signal transduction proteins
| Genomes | One-component | Two-component | Chemotaxis * | ECF | ||
|---|---|---|---|---|---|---|
| Archaea | Complete | 69 | 3,369 | 1,064 | 464 | 0 |
| Archaea | Draft | 4 | 136 | 2 | 23 | 0 |
| Bacteria | Complete | 950 | 143,426 | 56,629 | 14,071 | 5,696 |
| Bacteria | Draft | 230 | 31,436 | 11,353 | 2,075 | 1,117 |
| Total | 1,253 | 178,367 | 69,048 | 16,633 | 6,813 |
Champion genomes:
- 1,140 signal transduction proteins: Streptosporangium roseum DSM 43021
- 818 one-component proteins: Streptosporangium roseum DSM 43021
- 287 two-component proteins: Paenibacillus sp. JDR-2
- 102 chemotaxis proteins: Clostridium carboxidivorans P7
- 101 ECF proteins: Catenulispora acidiphila DSM 44928
- Largest genome (13.0 Mbp): Sorangium cellulosum 'So ce 56'
- Most genes (9,703 genes): Sorangium cellulosum 'So ce 56'
* Note: Chemotaxis is a specialized form of two-component systems (details)
Recently viewed
Top 10 Google-ranked bacteria
| Escherichia coli | 1,740,000 |
| Staphylococcus aureus | 642,000 |
| Escherichia sp. | 538,000 |
| Pseudomonas aeruginosa | 391,000 |
| Helicobacter pylori | 351,000 |
| Bacillus subtilis | 297,000 |
| Mycobacterium tuberculosis | 278,000 |
| Streptococcus pneumoniae | 210,000 |
| Haemophilus influenzae | 139,000 |
| Klebsiella pneumoniae | 116,000 |
Bioinformatic tools
| Pfam 23 | 4,615,655 | domains |
| Agfam 1 | 208,093 | signaling domains |
| DAS 5 | 4,694,410 | transmembrane regions |
| Coils 2.01 | 514,702 | coiled-coils |
| Seg | 4,889,412 | low-complexity regions |
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